Drawing on a qualitative analysis of Swedish newspaper debates in 1979 and 1995, this article examines how Swedish newspapers refer to biological sex difference as central to drinking practices. The study shows that women are a special category of concern in debate about gender and drinking in both 1979 and 1995. Further, it shows that Swedish newspapers draw upon biology in different ways in the two years. In 1979, debate about drinking during pregnancy and Fetal Alcohol Syndrome (FAS) is central and newspapers link biomedical research on FAS to the moral idea that mothers do anything to avoid harm to children. In 1995, debate about girls' drinking habits is central and newspapers link sex hormones and neurotransmitters to the moral idea that girls shouldn't “drink like men.” These differences are discussed in the context of Swedish media interest in evolutionary psychology and biomedical solutions to alcohol problems during the 1990s.