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RNAi mediates post-transcriptional repression of gene expression in fission yeast Schizosaccharomyces pombe
Södertörns högskola, Institutionen för naturvetenskap, miljö och teknik, Biologi. Karolinska instiutet.
Karolinska instiutet.
Karolinska instiutet.
Södertörns högskola, Institutionen för naturvetenskap, miljö och teknik, Biologi.
Vise andre og tillknytning
2014 (engelsk)Inngår i: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 444, nr 2, s. 254-259Artikkel i tidsskrift (Annet vitenskapelig) Published
Abstract [en]

RNA interference (RNAi) is a gene silencing mechanism conserved from fungi to mammals. Small interfering RNAs are products and mediators of the RNAi pathway and act as specificity factors in recruiting effector complexes. The Schizosaccharomyces pombe genome encodes one of each of the core RNAi proteins, Dicer, Argonaute and RNA-dependent RNA polymerase (dcr1, ago1, rdp1). Even though the function of RNAi in heterochromatin assembly in S. pombe is established, its role in controlling gene expression is elusive. Here, we report the identification of small RNAs mapped anti-sense to protein coding genes in fission yeast. We demonstrate that these genes are up-regulated at the protein level in RNAi mutants, while their mRNA levels are not significantly changed. We show that the repression by RNAi is not a result of heterochromatin formation. Thus, we conclude that RNAi is involved in post-transcriptional gene silencing in S. pombe.

sted, utgiver, år, opplag, sider
2014. Vol. 444, nr 2, s. 254-259
Emneord [en]
Fission yeast, PTGS, RNAi
HSV kategori
Identifikatorer
URN: urn:nbn:se:sh:diva-22232DOI: 10.1016/j.bbrc.2014.01.057ISI: 000331923500025PubMedID: 24462781Scopus ID: 2-s2.0-84892926000OAI: oai:DiVA.org:sh-22232DiVA, id: diva2:696634
Forskningsfinansiär
The Foundation for Baltic and East European Studies, 300501Swedish Cancer Society, CAN-2009Swedish Research Council, VR-NT-2007-4722Tilgjengelig fra: 2014-02-14 Laget: 2014-02-14 Sist oppdatert: 2018-07-20bibliografisk kontrollert

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Smialowska, AgataKylsten, PerSwoboda, PeterEkwall, Karl

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