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Heterochromatin tells CENP-A where to go
Södertörns högskola, Institutionen för livsvetenskaper.
Södertörns högskola, Institutionen för livsvetenskaper.
2008 (engelsk)Inngår i: Bioessays, ISSN 0265-9247, E-ISSN 1521-1878, Vol. 30, nr 6, s. 526-529Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The centromere is the region of the chromosome where the kinetochore forms. Kinetochores are the attachment sites for spindle microtubules that separate duplicated chromosomes in mitosis and meiosis. Kinetochore formation depends on a special chromatin structure containing the histone H3 variant CENP-A. The epigenetic mechanisms that maintain CENP-A chromatin throughout the cell cycle have been studied extensively but little is known about the mechanism that targets CENP-A to naked centromeric DNA templates. In a recent report published in Science,((1)) such de novo centromere assembly of CENP-A is shown to be dependent on heterochromatin and the RNA interference pathway.

sted, utgiver, år, opplag, sider
2008. Vol. 30, nr 6, s. 526-529
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URN: urn:nbn:se:sh:diva-14149DOI: 10.1002/bies.20763ISI: 000256608700003Scopus ID: 2-s2.0-45549091508OAI: oai:DiVA.org:sh-14149DiVA, id: diva2:467024
Tilgjengelig fra: 2011-12-18 Laget: 2011-12-16 Sist oppdatert: 2017-12-08bibliografisk kontrollert

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Durand-Dubief, MickaelEkwall, Karl

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