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Immunogenicity and antigenic properties of Pf332-C231, a fragment of a non-repeat region of the Plasmodium falciparum antigen Pf332
Södertörns högskola, Institutionen för livsvetenskaper.
Vise andre og tillknytning
2009 (engelsk)Inngår i: Vaccine, ISSN 0264-410X, E-ISSN 1873-2518, Vol. 28, nr 1, s. 90-97Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Antigen Pf332, a megadalton protein has been shown to be associated with the membrane of infected erythrocytes Detailed functional studies on the antigen have remained hampered by the cross-reactive nature of antibodies generated to Pf332 PB32-C231, identified in the C-terminal region of Pf332 was cloned and antibodies against the C231 fragment were shown to react with intact Pf332 antigen by both immunofluorescence and immunoblotting analyses Antibodies to C231 inhibited in vitro Plasmodium falciparum growth efficiently In addition. human sera from malaria-exposed individuals reacted with recombinant C231 We show that Pf332-C231 represents a functional domain and is expected to facilitate further studies on Pf332 as a potential target for protective immune responses and the function of the antigen.

sted, utgiver, år, opplag, sider
2009. Vol. 28, nr 1, s. 90-97
HSV kategori
Identifikatorer
URN: urn:nbn:se:sh:diva-13873DOI: 10.1016/j.vaccine.2009.09.110ISI: 000274869200012PubMedID: 19822232Scopus ID: 2-s2.0-70649086102OAI: oai:DiVA.org:sh-13873DiVA, id: diva2:465577
Tilgjengelig fra: 2011-12-14 Laget: 2011-12-14 Sist oppdatert: 2017-12-08bibliografisk kontrollert

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