Open this publication in new window or tab >>2008 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 370, no 4, p. 657-662Article in journal (Refereed) Published
Abstract [en]
Drosophila PNS sense organs arise from single sensory organ precursor (SOP) cells through a series of asymmetric divisions. In a mis-expression screen for factors affecting PNS development, we identified string and dappled as being important for the proper formation of adult external sensory (ES) organs. string is a G2 regulator. dappled has no described function but is implicated in tumorigenesis. The misexpression effect from string was analysed using timed over expression during adult ES-organ and, for comparison, embryonic Chorclotonal (Ch) organ formation. Surprisingly, string mis-expression prior to SOP division gave the greatest effect in both systems. In adult ES-organs, this lead to cell fate transformations producing structural cells, whilst in the embryo organs were lost, hence differences within the lineages exist. Mis-expression of dappled, lead to loss and duplications of entire organs in both systems, potentially affecting SOP specification, in addition to affecting neuronal guidance.
National Category
Biochemistry and Molecular Biology
Identifiers
urn:nbn:se:sh:diva-14146 (URN)10.1016/j.bbrc.2008.04.030 (DOI)000255883900025 ()18420029 (PubMedID)2-s2.0-43049164296 (Scopus ID)
Note
Som manuskript i avhandling. As manuscript in dissertation.
2011-12-182011-12-162017-12-08Bibliographically approved