Öppna denna publikation i ny flik eller fönster >>Visa övriga...
2004 (Engelska)Ingår i: Insect Biochemistry and Molecular Biology, ISSN 0965-1748, E-ISSN 1879-0240, Vol. 34, nr 12, s. 1297-1304Artikel i tidskrift (Refereegranskat) Published
Abstract [en]
Our studies on the developmental regulation of glycosylation in Drosophila melanogaster led us to identify and characterize gp 150, an ecdysone-regulated mucin that is found in hemocytes, the gut (peritrophic membrane) and in the salivary glands. We are particularly interested in mucin immune functions and found that gp 150 is released from larval hemocytes, becomes part of the clot and participates in the entrapment of bacteria. By RT-PCR and RNAi experiments, we identified gp 150 as the previously described 171-7, an ecdysone-induced salivary glue protein. We discuss the evolutionary and biochemical implications of the dual use of salivary proteins for immune functions in insects. Further molecular characterization of such shared proteins may enable a better understanding of the properties of proteins involved in containment and elimination of microbes, as well as hemostasis and wound repair.
Nationell ämneskategori
Biokemi och molekylärbiologi
Identifikatorer
urn:nbn:se:sh:diva-15456 (URN)10.1016/j.ibmb.2004.09.001 (DOI)000225515000007 ()15544943 (PubMedID)2-s2.0-8644286464 (Scopus ID)
2012-02-212012-02-202017-12-07Bibliografiskt granskad