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ABCE1 Is a Highly Conserved RNA Silencing Suppressor
Tallinn University of Technology, Tallinn, Estonia / Competence Centre for Cancer Research, Tallinn, Estonia .
Tallinn University of Technology, Tallinn, Estonia / Competence Centre for Cancer Research, Tallinn, Estonia .
Tallinn University of Technology, Tallinn, Estonia.
Tallinn University of Technology, Tallinn, Estonia.
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2015 (Engelska)Ingår i: PLOS ONE, E-ISSN 1932-6203, Vol. 10, nr 2, artikel-id e0116702Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

ATP-binding cassette sub-family E member 1 (ABCE1) is a highly conserved protein among eukaryotes and archaea. Recent studies have identified ABCE1 as a ribosome-recycling factor important for translation termination in mammalian cells, yeast and also archaea. Here we report another conserved function of ABCE1. We have previously described AtRLI2, the homolog of ABCE1 in the plant Arabidopsis thaliana, as an endogenous suppressor of RNA silencing. In this study we show that this function is conserved: human ABCE1 is able to suppress RNA silencing in Nicotiana benthamiana plants, in mammalian HEK293 cells and in the worm Caenorhabditis elegans. Using co-immunoprecipitation and mass spectrometry, we found a number of potential ABCE1-interacting proteins that might support its function as an endogenous suppressor of RNA interference. The interactor candidates are associated with epigenetic regulation, transcription, RNA processing and mRNA surveillance. In addition, one of the identified proteins is translin, which together with its binding partner TRAX supports RNA interference.

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2015. Vol. 10, nr 2, artikel-id e0116702
Nationell ämneskategori
Biologiska vetenskaper
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URN: urn:nbn:se:sh:diva-26400DOI: 10.1371/journal.pone.0116702ISI: 000349444900060PubMedID: 25659154Scopus ID: 2-s2.0-84922720162OAI: oai:DiVA.org:sh-26400DiVA, id: diva2:787992
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Östersjöstiftelsen, 300501Tillgänglig från: 2015-02-12 Skapad: 2015-02-12 Senast uppdaterad: 2021-06-14Bibliografiskt granskad

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Smialowska, AgataKylsten, PerEkwall, KarlSwoboda, Peter

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Smialowska, AgataKylsten, PerEkwall, KarlSwoboda, Peter
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