This paper will explore the relationship between selfhood and depression, by focusing upon the lived body’s capacity to “resonate” with the world and thus open up an “attuned” space of meaning. Persons will become differently tuned in different situations because they embody different patterns of resonance—what is most often referred to as different temperaments—but the self may also suffer from idiosyncrasies in mood profile that develop into deficiencies of resonance, making the person in question ill. In many cases of depression one might describe this as a being out of tune in the sense of being oversensitive to the sad, anxious and boring tune qualities of the world. This phenomenological model allows us to describe a spectrum of various normal sensitivities which might favor certain moods over others, but also to identify pathologies, like depression, in which the body is out of tune and makes the being-in-the-world overwhelmingly unhomelike.