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DNA fragmentation and morphological changes in apoptotic human lymphocytes
Södertörns högskola, Avdelning Naturvetenskap.
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2002 (Engelska)Ingår i: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 294, nr 4, s. 872-878Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Cell suspensions enriched in cells at various stages of apoptosis were obtained by separation of irradiated human peripheral blood lymphocytes on density gradients at different post-irradiation times. The state of DNA fragmentation in the cells was determined by comet assay and pulsed field gel electrophoresis. The morphologically distinguishable features of apoptosis such as chromatin condensation and cell shrinkage correlated with discrete stages of DNA fragmentation. It was found that greater than or equal to50kbp fragmentation of DNA occurs already in cells of normal density whereas the subsequent DNA fragmentation onto fragments <50 kbp occurs in parallel with cell shrinkage and simultaneous increase in cell density. The observed stages of DNA fragmentation seem to be separated in time that could allow in case of abortive apoptosis formation of chromosomal aberrations.

Ort, förlag, år, upplaga, sidor
2002. Vol. 294, nr 4, s. 872-878
Nationell ämneskategori
Biokemi och molekylärbiologi
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URN: urn:nbn:se:sh:diva-15800DOI: 10.1016/S0006-291X(02)00588-0ISI: 000176490100020PubMedID: 12061788OAI: oai:DiVA.org:sh-15800DiVA, id: diva2:508349
Tillgänglig från: 2012-03-08 Skapad: 2012-03-07 Senast uppdaterad: 2017-12-07Bibliografiskt granskad

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