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Smoking is associated with mosaic loss of chromosome Y
Uppsala University.
Uppsala University.
Södertörns högskola, Institutionen för naturvetenskap, miljö och teknik, Biologi.ORCID-id: 0000-0002-5013-6462
Uppsala University.
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2015 (Engelska)Ingår i: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 347, nr 6217, s. 81-83Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Tobacco smoking is a risk factor for numerous disorders, including cancers affecting organs outside the respiratory tract. Epidemiological data suggest that smoking is a greater risk factor for these cancers in males compared to females. This observation, together with the fact that males have a higher incidence of and mortality from most non-sex-specific cancers, remains unexplained. Loss of chromosome Y (LOY) in blood cells is associated with increased risk of nonhematological tumors. We demonstrate here that smoking is associated with LOY in blood cells in three independent cohorts [TwinGene: odds ratio (OR) = 4.3, 95% CI = 2.8-6.7; ULSAM: OR = 2.4, 95% CI = 1.6-3.6; and PIVUS: OR = 3.5, 95% CI = 1.4-8.4] encompassing a total of 6014 men. The data also suggest that smoking has a transient and dose-dependent mutagenic effect on LOY status. The finding that smoking induces LOY thus links a preventable risk factor with the most common acquired human mutation.

Ort, förlag, år, upplaga, sidor
2015. Vol. 347, nr 6217, s. 81-83
Nationell ämneskategori
Biologiska vetenskaper
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URN: urn:nbn:se:sh:diva-25492DOI: 10.1126/science.1262092ISI: 000347102300053PubMedID: 25477213Scopus ID: 2-s2.0-84922481318OAI: oai:DiVA.org:sh-25492DiVA, id: diva2:771624
Tillgänglig från: 2014-12-15 Skapad: 2014-12-15 Senast uppdaterad: 2018-04-05Bibliografiskt granskad

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