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Targeting cytokine expression in glial cells by cellular delivery of an NF-kappa B decoy
Vise andre og tillknytning
2007 (engelsk)Inngår i: Journal of Molecular Neuroscience, ISSN 0895-8696, E-ISSN 1559-1166, Vol. 31, nr 3, s. 209-219Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Inhibition of nuclear factor (NF)-kappa B has emerged as an important strategy for design of anti-inflammatory therapies. In neurodegenerative disorders like Alzheimer's disease, inflammatory reactions mediated by glial cells are believed to promote disease progression. Here, we report that uptake of a double-stranded oligonucleotide NF-kappa B decoy in rat primary glial cells is clearly facilitated by noncovalent binding to a cell-penetrating peptide, transportan 10, via a complementary peptide nucleic acid (PNA) sequence. Fluorescently labeled oligonucleotide decoy was detected in the cells within 1 h only when cells were incubated with the decoy in the presence of cell-penetrating peptide. Cellular delivery of the decoy also inhibited effects induced by a neurotoxic fragment of the Alzheimer beta-amyloid peptide in the presence of the inflammatory cytokine interleukin (IL)-1 beta. Pretreatment of the cells with the complex formed by the decoy and the cell-penetrating peptide-PNA resulted in 80% and 50% inhibition of the NF-kappa B binding activity and IL-6 mRNA expression, respectively.

sted, utgiver, år, opplag, sider
2007. Vol. 31, nr 3, s. 209-219
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URN: urn:nbn:se:sh:diva-14252DOI: 10.1385/JMN:31:03:209ISI: 000246588800003PubMedID: 17726227Scopus ID: 2-s2.0-34548336397OAI: oai:DiVA.org:sh-14252DiVA, id: diva2:467141
Tilgjengelig fra: 2011-12-19 Laget: 2011-12-19 Sist oppdatert: 2024-02-05bibliografisk kontrollert

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