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Bhuiyan, Hasanuzzaman
Publications (1 of 1) Show all publications
Strålfors, A., Walfridsson, J., Bhuiyan, H. & Ekwall, K. (2011). The FUN30 Chromatin Remodeler, Fft3, Protects Centromeric and Subtelomeric Domains from Euchromatin Formation. PLOS Genetics, 7(3), Article ID e1001334.
Open this publication in new window or tab >>The FUN30 Chromatin Remodeler, Fft3, Protects Centromeric and Subtelomeric Domains from Euchromatin Formation
2011 (English)In: PLOS Genetics, ISSN 1553-7390, E-ISSN 1553-7404, Vol. 7, no 3, article id e1001334Article in journal (Refereed) Published
Abstract [en]

The chromosomes of eukaryotes are organized into structurally and functionally discrete domains. This implies the presence of insulator elements that separate adjacent domains, allowing them to maintain different chromatin structures. We show that the Fun30 chromatin remodeler, Fft3, is essential for maintaining a proper chromatin structure at centromeres and subtelomeres. Fft3 is localized to insulator elements and inhibits euchromatin assembly in silent chromatin domains. In its absence, euchromatic histone modifications and histone variants invade centromeres and subtelomeres, causing a mis-regulation of gene expression and severe chromosome segregation defects. Our data strongly suggest that Fft3 controls the identity of chromatin domains by protecting these regions from euchromatin assembly.

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Genetics
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urn:nbn:se:sh:diva-14962 (URN)10.1371/journal.pgen.1001334 (DOI)000288996600016 ()21437270 (PubMedID)2-s2.0-79953741267 (Scopus ID)
Available from: 2012-01-24 Created: 2012-01-24 Last updated: 2022-09-13Bibliographically approved
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