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Munoz-Alarcon, Andres
Publications (2 of 2) Show all publications
Munoz-Alarcon, A., Pavlovic, M., Wismar, J., Schmitt, B., Eriksson, M., Kylsten, P. & Dushay, M. S. (2007). Characterization of lamin Mutation Phenotypes in Drosophila and Comparison to Human Laminopathies. PLOS ONE, 2(6), e532
Open this publication in new window or tab >>Characterization of lamin Mutation Phenotypes in Drosophila and Comparison to Human Laminopathies
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2007 (English)In: PLOS ONE, E-ISSN 1932-6203, Vol. 2, no 6, p. e532-Article in journal (Refereed) Published
Abstract [en]

Lamins are intermediate filament proteins that make up the nuclear lamina, a matrix underlying the nuclear membrane in all metazoan cells that is important for nuclear form and function. Vertebrate A-type lamins are expressed in differentiating cells, while B-type lamins are expressed ubiquitously. Drosophila has two lamin genes that are expressed in A-and B-type patterns, and it is assumed that similarly expressed lamins perform similar functions. However, Drosophila and vertebrate lamins are not orthologous, and their expression patterns evolved independently. It is therefore of interest to examine the effects of mutations in lamin genes. Mutations in the mammalian lamin A/C gene cause a range of diseases, collectively called laminopathies, that include muscular dystrophies and premature aging disorders. We compared the sequences of lamin genes from different species, and we have characterized larval and adult phenotypes in Drosophila bearing mutations in the lam gene that is expressed in the B-type pattern. Larvae move less and show subtle muscle defects, and surviving lam adults are flightless and walk like aged wild-type flies, suggesting that lam phenotypes might result from neuromuscular defects, premature aging, or both. The resemblance of Drosophila lam phenotypes to human laminopathies suggests that some lamin functions may be performed by differently expressed genes in flies and mammals. Such still-unknown functions thus would not be dependent on lamin gene expression pattern, suggesting the presence of other lamin functions that are expression dependent. Our results illustrate a complex interplay between lamin gene expression and function through evolution.

National Category
Biological Sciences
urn:nbn:se:sh:diva-14220 (URN)10.1371/journal.pone.0000532 (DOI)000207451600020 ()2-s2.0-70349566715 (Scopus ID)
Available from: 2011-12-19 Created: 2011-12-19 Last updated: 2021-06-14Bibliographically approved
O'Farrell, F., Munoz-Alarcón, A., Georgiev, A. & Kylsten, P.Functional Analysis of Drosophila lin-41, dappled during adult eye development.
Open this publication in new window or tab >>Functional Analysis of Drosophila lin-41, dappled during adult eye development
(English)Manuscript (preprint) (Other academic)
National Category
Biological Sciences
urn:nbn:se:sh:diva-31552 (URN)

Som manuskript i avhandling. As manuscript in dissertation.

Available from: 2016-12-29 Created: 2016-12-29 Last updated: 2016-12-29Bibliographically approved

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