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Syed, Asim
Publications (1 of 1) Show all publications
Ellencrona, K., Syed, A. & Johansson, M. (2009). Flavivirus NS5 associates with host-cell proteins zonula occludens-1 (ZO-1) and regulating synaptic membrane exocytosis-2 (RIMS2) via an internal PDZ binding mechanism. Biological chemistry (Print), 390(4), 319-323
Open this publication in new window or tab >>Flavivirus NS5 associates with host-cell proteins zonula occludens-1 (ZO-1) and regulating synaptic membrane exocytosis-2 (RIMS2) via an internal PDZ binding mechanism
2009 (English)In: Biological chemistry (Print), ISSN 1431-6730, E-ISSN 1437-4315, Vol. 390, no 4, p. 319-323Article in journal (Refereed) Published
Abstract [en]

Dengue virus (DENV) and tick-borne encephalitis virus (TBEV) are flaviviruses, which can cause lethal hemorrhagic fever and encephalitis, respectively. Here, we demonstrate that the TBEV-NS5 and DENV-NS5 proteins use an internal binding mechanism to target human PDZ proteins. TBEV-NS5 has high affinity to regulating synaptic membrane exocytosis-2 (RIMS2) and Scribble, whereas DENV-NS5 binds primarily to the tight junction protein zonula occludens-1 (ZO-1). Targeting of TBEV-NS5 to the plasma membrane is stabilised by ZO-1; however, DENV-NS5 co-localises with ZO-1 in the nucleus. These interactions have potential important roles in the ability of flaviviruses to manipulate cell proliferation, junction permeability and the interferon pathways.

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Medical and Health Sciences
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urn:nbn:se:sh:diva-6056 (URN)10.1515/BC.2009.041 (DOI)000265160000005 ()19199833 (PubMedID)2-s2.0-64849087370 (Scopus ID)
Available from: 2011-02-07 Created: 2011-02-07 Last updated: 2017-12-11Bibliographically approved
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